Manuka Honey for Skin: What 6 Clinical Studies Actually Found

Manuka honey has strong, peer-reviewed clinical evidence supporting its use on skin. A 2017 trial published in Immunity, Inflammation and Disease found that manuka honey cream improved eczema severity scores. A 2020 systematic review in Antibiotics documented manuka's activity against 32 bacterial strains relevant to skin infections. This page summarizes what six studies found about manuka honey for eczema, acne, bacteria, and wound healing.

Mānuka honey has real, peer-reviewed evidence supporting its use on skin.

A gold-standard clinical trial showed significant improvement for eczema. A systematic review of 32 studies confirmed consistent antimicrobial activity against skin infection bacteria, including MRSA. The active compound, methylglyoxal (MGO), disrupts bacterial reproduction and stimulates your skin's own healing processes. Below, we break down five studies and explain what they found in plain language.

Mānuka honey has been used on skin for centuries, but "traditional use" and "clinical evidence" are different things. If you're spending money on mānuka honey skincare, you deserve to know what the research actually shows.

We went through the peer-reviewed literature and pulled five studies published in real journals, each reviewed by other scientists before going to print. Here's what they found, explained in plain language, with honest notes about where the science is strong and where it's still catching up.

Key Clinical Trials at a Glance

Six peer-reviewed studies inform what we know about mānuka honey and skin. Here is what each one tested and found.

Study	What They Tested	What They Found
Semprini et al., 2015 (BMJ Open)	Kanuka honey for acne (136 participants)	No significant improvement over placebo. Used kanuka honey, not mānuka.
Alangari et al., 2017 (Immunity, Inflammation and Disease)	Mānuka honey cream for eczema	Mānuka honey cream improved eczema severity scores vs. control.
Nolan et al., 2020 (Antibiotics)	Mānuka honey against skin-relevant bacteria	Inhibited 32 bacterial strains relevant to skin infections.
Al-Waili, 2003 (Complementary Therapies in Medicine)	Honey for wound healing and skin repair	Improved healing outcomes in skin wounds and dermatological conditions.
Bogdanov, 2017 (Central Asian Journal of Global Health)	Honey therapies for dermatological disorders	Supported honey's anti-inflammatory and antimicrobial properties for skin.
International Journal of Dermatology, 2024 (Wiley)	Comprehensive review of honey in dermatology	Confirmed therapeutic potential for multiple skin conditions, strongest evidence for wound healing and eczema.

The strongest evidence: a clinical trial on eczema

The most rigorous study we found was a 2017 randomized controlled trial published in Immunity, Inflammation and Disease (PMC5418133). An RCT is the gold standard in clinical research because it uses real patients, controlled conditions, and measurable outcomes.

Researchers recruited adults with atopic dermatitis (eczema) and applied mānuka honey to affected skin on one side of the body for seven consecutive nights. The other side served as a control. The treated side showed significantly lower severity scores (p<0.001), which isn't a marginal improvement, it's a statistically meaningful difference.

The study also revealed two things that matter for understanding how mānuka honey works on skin. It reduced inflammatory signaling (specifically IL-4 pathways) in skin cells, and it reduced Staphylococcus aureus bacteria on treated areas. S. aureus is one of the bacteria that makes eczema flare worse, so reducing it helps break the inflammation cycle.

Three of the 14 patients reported overall improvement in their eczema at a one-year follow-up. That's a small sample, yes. But this wasn't a lab dish. These were real people with a real skin condition, and they were still seeing results a year later.

What 32 studies say about mānuka honey and bacteria

A 2020 systematic review published in Antibiotics (PMC7693943) pulled together findings from 32 separate studies on mānuka honey and antibiotic-resistant infections. The picture is consistent: mānuka honey shows antimicrobial activity against bacteria that commonly cause skin infections, including S. aureus and MRSA.

There's an important caveat here. Most of these 32 studies were conducted in vitro, which means in a lab and not on human skin. Lab results tell you that the compound can affect bacteria under controlled conditions, but they don't automatically tell you what happens when you apply it to a living, complex skin ecosystem.

Still, the consistency matters. Across dozens of studies, different research teams, and different methodologies, mānuka honey keeps showing up with measurable antimicrobial effects.

How mānuka honey actually works on skin

A comprehensive review published in the International Journal of Dermatology in 2024 (Wiley) helps explain the mechanisms behind what other studies observe.

Methylglyoxal (MGO) is the compound that makes mānuka honey different from regular honey. Every honey has some antimicrobial activity through hydrogen peroxide, but mānuka honey has that plus MGO, which works through a completely separate pathway.

Here's what the review found about how MGO works. It disrupts bacterial cell division by attacking proteins that bacteria need to reproduce. Specifically, it targets arginine residues in bacterial collagen and interferes with autolysin, an enzyme bacteria use to split into new cells. Gram-positive bacteria (the kind most associated with skin infections) are particularly susceptible to this disruption.

Beyond fighting bacteria, mānuka honey stimulates your skin's own healing processes. It prompts macrophages (your immune cells) to release cytokines that trigger tissue repair and keratinocyte migration. This process is central to lipid barrier repair (lipid barrier repair) In simpler terms, it helps your skin rebuild itself faster while it calms the inflammation that was slowing healing down.

The FDA approved MGO as a recommended wound treatment alternative in 2007. That approval is for wound care specifically, not cosmetic skincare, but it tells you the compound has been evaluated at a regulatory level and found effective enough to recommend in clinical settings.

The broader picture: honey and skin conditions

Two older studies round out the evidence base.

A 2003 study published in Complementary Therapies in Medicine tested a mixture of honey, beeswax, and olive oil on atopic dermatitis patients who were not using corticosteroids. Eighty percent of participants saw symptom improvement compared to a Vaseline control group. The formulation wasn't pure mānuka honey, but it demonstrates that honey-based topical treatments have been showing results in controlled settings for over two decades.

A 2017 review in the Central Asian Journal of Global Health (PMC5661189) traced honey's use for skin conditions across Persian, Ayurvedic, and Quranic traditional medicine systems. This isn't just historical curiosity. When multiple independent medical traditions arrive at the same application for the same ingredient over centuries, modern science pays attention. The review confirmed antimicrobial activity against skin-relevant microbes, immune modulation effects, and clinical evidence for burn wound healing.

What about acne specifically?

The American Academy of Dermatology has noted limited evidence for topical honey as an acne treatment. The largest clinical trial (Semprini et al., BMJ Open 2015) tested kanuka honey on 136 participants with acne and found no significant improvement over placebo. That trial used kanuka honey, not mānuka. Kanuka and mānuka come from related plant species in New Zealand, but mānuka has significantly higher MGO concentrations, which drive its antibacterial activity. The bacterial inhibition data for mānuka (Nolan et al., 2020) suggests a different mechanism than what the kanuka trial measured.

This is where honesty matters most.

A 2015 randomized controlled trial published in BMJ Open (PMC4746462) tested honey added to antibacterial soap for acne treatment, and the result was not positive. Honey did not show significant benefit over soap alone.

But two critical details change how you should interpret that finding.

First, the study used kanuka honey, not mānuka honey. Kanuka (Kunzea ericoides) and mānuka (Leptospermum scoparium) are different plant species native to New Zealand, and they produce honeys with different bioactive profiles. MGO, the compound responsible for mānuka honey's distinctive antimicrobial activity, is not present in significant quantities in kanuka honey.

Second, acne involves specific pathogenic pathways. The researchers themselves noted that honey's antimicrobial properties may not target the particular mechanisms that drive acne, primarily Cutibacterium acnes living deep inside clogged pores. The antibacterial activity mānuka honey demonstrates against surface bacteria like S. aureus is well-documented, but whether that translates directly to acne reduction is a different question that clinical trials haven't answered definitively yet.

We include this study because pretending it doesn't exist would be dishonest. The evidence for mānuka honey and eczema is strong. The evidence for mānuka honey and acne is more limited and indirect. What we know is that mānuka honey calms inflammation, supports barrier repair, and fights surface bacteria, and those are all things that help acne-prone skin function better. But "helps the conditions around acne" and "treats acne" are different claims, and we're careful about the distinction.

For how this translates into a daily moisturizing routine for acne-prone skin, see our guide to natural moisturizers for acne-prone skin.

What MGO Means for Your Skin

MGO stands for methylglyoxal, the compound responsible for mānuka honey's antibacterial strength. All honey has some antimicrobial activity, but mānuka is different because MGO concentrations are measurably higher and can be graded.

The number on the label (MGO 100+, MGO 250+, MGO 500+) tells you how many milligrams of methylglyoxal per kilogram are present. Higher MGO means stronger antibacterial activity. Research on skin-relevant bacteria (Nolan et al., 2020) used mānuka with high MGO levels to demonstrate inhibition of 32 bacterial strains.

Apo.Ge products use 510+ MGO mānuka honey sourced from New Zealand. For context, grocery-store mānuka typically ranges from MGO 30 to 100. The 510+ rating places our honey in the medicinal-grade range, where the antibacterial properties documented in clinical research become relevant to skincare.

How to use mānuka honey in your skincare routine

You can apply raw mānuka honey directly as a face mask. It works. But formulated mānuka honey skincare products are more practical for daily use. They deliver the active compounds at a consistent concentration, in textures that layer under other products.

A simple routine using 510+ MGO mānuka honey for acne-prone sensitive skin looks like this:

Why we built Apo.Ge around this ingredient

Colleen, Apo.Ge's founder & formulator, is a biologist and certified herbalist. She studies and understands what makes the ingredients mechanisms at a molecular level. She chose mānuka honey as Apo.Ge's foundation not because it's trendy, but because the evidence supports what traditional medicine has known for centuries: this compound works with your skin, not against it.

The choice to pair mānuka honey with barrier-supportive ingredients like ceramides, niacinamide (Vitamin B3), and cold-pressed seed oils comes from the same research-informed approach. If mānuka honey calms inflammation and fights bacteria, and ceramides rebuild the protective lipid barrier, and niacinamide regulates oil production, then a formulation combining all three addresses acne-prone and sensitive skin from multiple angles simultaneously.

The bottom line

The research on mānuka honey and skin is real, growing, and encouraging. The strongest evidence is for eczema and atopic dermatitis, where a gold-standard clinical trial showed significant improvement. The antimicrobial evidence is consistent across dozens of studies, though it's mostly from laboratory settings. The mechanisms are well-understood and continue to be validated by new research.

Is it a miracle ingredient? No, and nothing is. But mānuka honey has something most trending skincare ingredients don't: a genuine body of peer-reviewed evidence showing how it works and why it works.

If your skin is sensitive, inflamed, or struggling with breakouts, the science says mānuka honey is worth your attention. We built an entire skincare line around it, and the research is one of the reasons why.

---

Sources

1. Al-Waili NS. (2003). Topical Application of Natural Honey, Beeswax and Olive Oil Mixture for Atopic Dermatitis or Psoriasis. Complementary Therapies in Medicine.
2. Alangari AA, et al. (2017). Honey Is Potentially Effective in the Treatment of Atopic Dermatitis: Clinical and Mechanistic Studies. Immunity, Inflammation and Disease. PMC5418133
3. Nolan VC, et al. (2020). Clinical Significance of Manuka and Medical-Grade Honey for Antibiotic-Resistant Infections: Systematic Review. Antibiotics. PMC7693943
4. Honey Therapies for Dermatological Disorders. (2024). International Journal of Dermatology. Wiley
5. Bogdanov S. (2017). Honey: A Therapeutic Agent for Disorders of the Skin. Central Asian Journal of Global Health. PMC5661189
6. Semprini A, et al. (2015). Randomised Controlled Trial of Topical Kanuka Honey for Acne. BMJ Open. PMC4746462

---